abstract

The elderly are disproportionately affected by these diseases. An example of this is In the United States, the sixth leading cause of death in adults is Alzheimer's disease (AD). To identify miR biomarkers in PD, we used transcriptomic and text mining approaches as part of a computational systems biology investigation of the disease. In order to understand the recurring pattern of regulation peculiar to AD, several network motifs were examined, including Feed Forward Loops (FFLs), Feed Back Loops (FBLs), and Multiple Input Modules (MIMs). Additionally, the study examined this network motif's epigenetic regulation in connection to miR-related lncRNAs, histone modification pattern, and DNA islands inside the miR promoter region. The function of these authorities in Alzheimer's disease was further reinforced by the results of the tissue specificity study.